Hoag Family Cancer Institute | Pickup Family Neurosciences Institute
(949) 722-6237
Our clinical trials in the areas of brain tumors and immunotherapy/cell therapy provide groundbreaking treatments that are helping to beat the odds against brain cancer.
Hoag is the top choice for cancer care in Orange County, with cancer survival rates that continually exceed national averages. Our dedicated, world-class teams are wholly focused on helping you survive cancer, heal and move forward with your life.










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Contact usCraniopharyngiomas are tumors that begin between the bottom of the brain and the pituitary gland. These tumors often press on the hypothalamus or the pituitary gland, and can cause issues with hormone secretion. Because they often occur close to the optic nerves, they can also cause problems with vision.
Glioblastomas (also called GBM) are grade 4 malignant (cancerous) tumors predominantly made up of abnormal astrocytic cells, but also contains a mix of different cell types (including blood vessels) and areas of dead cells (necrosis). Glioblastomas can invade nearby regions of the brain and may also sometimes spread to the opposite side of the brain. It is exceedingly rare for glioblastomas to spread outside of the brain and spinal cord.
Gliomas are tumors that start in specialized cells in the brain called glial cells. There are several subtypes of gliomas, including ependymomas, astrocytomas and oligodendrogliomas. According to the American Cancer Society, about 30% of brain tumors are gliomas.
Meningiomas are tumors that start in meninges, which are the tissues that cover the outer part of the brain and spinal cord. According to the ACS, meningiomas are the most common non-metastatic brain tumors in adults.
Gangliogliomas are rare, slow-growing tumors that include a mix of both abnormal glial cells and neurons.
Medulloblastomas are tumors that develop in the cerebellum from immature nerve cells called neuroectodermal cells. Medulloblastomas are more common in children and adults.
Schwannomas (AKA neurilemmomas) are tumors that develop from specialized cells that protect and insulate nerves called Schwann cells. These tumors can begin in any nerve in the skull. When they occur on the nerve that controls balance and hearing, they are called “vestibular schwannomas.” Other forms of schwannomas can intrude on the upper spinal cord, causing issues with bowel/bladder control, muscle weakness and other effects.
These rare tumors arise from remnants of the notochord and are typically located at the base of the skull or along the spine. They tend to grow slowly but can be aggressive and invasive, often requiring complex surgical approaches.
These malignant tumors arise from cartilaginous tissue and are less common. They often require aggressive treatment due to their potential to invade surrounding structures.
A colloid cyst is a slow-growing, benign cyst that forms near the center of the brain, often at the third ventricle. It can block the normal flow of cerebrospinal fluid, leading to headaches, dizziness, or in rare cases, sudden neurological symptoms. Minimally invasive surgery is often used to remove the cyst and restore fluid balance.
An epidermoid cyst of the brain is a rare, benign tumor that develops from skin-like cells trapped during brain formation. These cysts can grow slowly and press on nerves or brain tissue, causing symptoms like facial pain, hearing loss, or imbalance. Surgical removal is typically recommended for relief and to prevent recurrence.
Gliomas are a group of primary brain tumors that develop from glial cells — the supportive cells that surround and protect neurons in the brain. These tumors can vary in aggressiveness, growth rate, and treatment approach, depending on their type and grade. Treatment often includes a combination of surgery, radiation therapy, and chemotherapy, guided by advanced imaging and molecular diagnostics to tailor care for each patient.
Hemangioblastomas are rare, benign vascular tumors that occur in the brain or spinal cord. They may cause headaches, problems with balance, or other neurological symptoms depending on their location. Surgical removal is often curative, and ongoing monitoring is important, especially for patients with genetic conditions such as von Hippel-Lindau disease.
These are the most common primary tumors of the skull base. They are usually benign and originate from the meninges. Symptoms can vary depending on their location and size but may include headaches, seizures, or neurological deficits.
Metastatic brain tumors occur when cancer from another part of the body spreads to the brain. Symptoms depend on tumor size and location and can include headaches, seizures, or neurological changes. Treatment options include surgery, radiation, targeted therapy, or a combination to control growth and relieve symptoms.
Olfactory neuroblastoma, also known as esthesioneuroblastoma, is a rare cancer that develops in the upper nasal cavity near the smell nerves. Symptoms can include nasal congestion, nosebleeds, or loss of smell. Treatment often combines surgery, radiation therapy, and sometimes chemotherapy.
These are rare tumors that originate from paraganglia, collections of nerve cells. They are usually benign but can occasionally be malignant.
Sinonasal carcinoma refers to a group of cancers that develop in the nasal cavity or sinuses. These tumors may cause nasal congestion, facial pain, or swelling. Early diagnosis is critical, as treatment typically involves surgery followed by radiation or chemotherapy to preserve function and control disease.
Subependymomas are rare, typically slow-growing tumors that develop from the ependymal cells lining the ventricles of the brain or the central canal of the spinal cord; they are usually noncancerous. When symptoms occur, they may include headaches, balance issues, or changes in vision due to blockage of cerebrospinal fluid flow. Treatment often depends on the size and location of the tumor — some may only require observation, while others are surgically removed to relieve pressure and prevent complications.
These benign tumors develop on the vestibular nerve, which connects the inner ear with the brain. They can cause hearing loss, tinnitus, and balance issues as they grow.
These are generally benign tumors that occur in the pituitary gland. They can affect hormone levels, leading to various systemic symptoms like vision problems, headaches, or hormonal imbalances
Acromegaly is a rare disorder caused by the overproduction of growth hormone (GH). This excess GH leads to abnormal growth of bones, cartilage, and soft tissues in adults.
Cushing's disease is a specific type of Cushing's syndrome, a condition caused by prolonged exposure to high levels of the hormone cortisol. In Cushing's disease, the culprit is a non-cancerous tumor in the pituitary gland that produces too much adrenocorticotropic hormone (ACTH). This excess ACTH then signals the adrenal glands to produce excessive cortisol.
These benign tumors develop near the pituitary gland and can affect its function, leading to hormonal imbalances and vision problems.
A Rathke cleft cyst is a benign, fluid-filled cyst that develops near the pituitary gland. Though noncancerous, it can cause headaches, vision changes, or hormonal imbalances when it grows large enough to press on nearby structures. Treatment may involve monitoring or surgical drainage to relieve symptoms.
As Orange County’s top choice for cancer care, Hoag has deep expertise in treating challenging brain tumors, including gioblastoma, astrocytoma, oligodendroglioma, neningioma, ependymoma, medulloblastoma, germ cell tumors and other brain metastases and rare tumors. Our specialists have deep experience diagnosing and treating brain tumors, using groundbreaking techniques and the latest research to improve outcomes and save lives.
Using a collaborative, multidisciplinary approach, your medical team includes neurosurgeons, radiation oncologists, neuro oncologists, neuroimaging specialists, pathologists, nurse navigators and other support specialists working together as an integrated team. This group of experts regularly holds a brain tumor-specific conference to discuss diagnosis, treatment and management of your individual care.
Your physician will likely start by discussing your symptoms and your personal and family health history, followed by a thorough physical exam. If your doctor finds cause for concern, you will be referred to a specialist in conditions of the nervous system and brain. Depending on the outcome of that visit, you may be asked to complete certain tests or procedures. At Hoag, these may include:
Computed tomography (CT) scans
Magnetic resonance imaging (MRI) scans
Positron emission tomography (PET) scans
If these imaging tests find evidence of a brain tumor, your doctor may recommend a biopsy to determine the type of tumor and other factors. A stereotactic biopsy is performed by inserting a hollow needle through the skull and into the tumor to extract a small tissue sample, which is then tested in a lab.
Hoag’s Precision Medicine program combines genomics and genetics to develop targeted therapies, creating the highest degree of accuracy in the diagnosis, treatment and prevention of diseases. Using the latest advances in research, genomic technologies and targeted therapies, the program provides patients with the latest innovations in medicine. Learn more about Precision Medicine at Hoag.
Treatment options for brain tumors depend on many different factors, including your age, overall health, how much the tumor has spread, where it is located in your brain and other considerations.
At Hoag, treatment options for brain tumors may include:
Surgery, which is usually performed through an opening made in the skull called a craniotomy. Often, the surgeon will rely on detailed medical imaging scans to plan the surgery to minimize damage to healthy brain tissue, or advanced techniques like cortical mapping to help preserve more normal brain function. At Hoag, we utilize the only PET/MRI instrument in Orange County to precisely guide surgical intervention in the brain.
Precision Virtual Reality medical visualization platform by Surgical Theater
Hoag is also a leader in the use of Gamma Knife Radiosurgery (SRS) and conformal focused radiation therapy. Explore radiation oncology at Hoag.
Radiation therapy, which involves beaming radiation into the tumor to kill cancerous cells.
Drug therapy, including to help regulate the amount of hormones in the blood caused by tumors near the pituitary gland.
Chemotherapy, in which drugs that disrupt the growth of tumors are introduced into the blood, usually over a period of weeks or months.
Advanced immunotherapy and biologics, use a patient’s own cells and immune system to find and destroy tumor cells. Learn more about immunotherapy and cell therapy at Hoag.
Adoptive cell therapy (i.e. CAR-T cells) is a form of immunotherapy where immune cells are removed from a patient’s bloodstream, reprogrammed to attack a protein found in brain tumors and reintroduced to destroy cancer. CAR-T is showing huge potential for brain tumor treatment.
Genomically-guided therapy uses a patient’s DNA to determine which mutations affect responses to a particular drug and are most likely to be effective.
Oncolytic virotherapy is an emerging treatment that uses anticancer viruses to destroy cancerous tissues without causing harm to normal tissues.
Alternating tumor treating fields are mild, electrical fields that pulse through a patient to disrupt a tumor’s ability to grow and spread. The fields are delivered through a device worn on a patient’s scalp. Studies have shown promise in survival rates without many of the side effects of traditional treatment.
Hoag is committed to leading the way in state-of-the-art technologies and advanced treatment options. Part of this commitment includes clinical research with the goal of helping patients live longer, healthier lives. Through carefully planned clinical trials, researchers evaluate the safety and effectiveness of new ways to diagnose, treat and prevent diseases or conditions. Treatments studied in clinical trials might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. View clinical trials for brain cancer here.
When faced with a brain or spine tumor, you can trust you are with a top-ranked neurosurgical team at Hoag. Our neurosurgeons are leading experts in brain and spine conditions, with expertise in the latest minimally invasive techniques and groundbreaking technology.
The combined comprehensive resources available at the Hoag Family Cancer Institute and Pickup Family Neurosciences Institute deliver a best practice, integrated care setting, with access to the latest clinical trials, and your individual circumstances in mind.

Dr. Robert Louis, MD, is a highly trained and fellowship-certified brain and spine surgeon in Orange County, specializing in minimally invasive neurosurgical techniques. Raised in a Boston suburb, he completed his undergraduate studies at Boston University before earning his medical degree. He then pursued a prestigious neurosurgical residency at the University of Virginia under Dr. John Jane, completing over 1,200 cases across cranial and spinal neurosurgery. His training emphasized complex brain tumor, skull base, and pituitary surgery, including extensive mentorship under Dr. Edward Oldfield, a world-renowned pituitary surgeon. To further refine his expertise, Dr. Louis completed a fellowship in Minimally Invasive Neurosurgery at the John Wayne Cancer Institute under Dr. Daniel Kelly, making him the only fellowship-trained minimally invasive neurosurgeon in Orange County. </span></p> <p dir="ltr"><span>As the Director of the Skull Base and Pituitary Tumor Program at Hoag Memorial Hospital, Dr. Louis specializes in endoscopic and minimally invasive procedures for brain, skull base, and sellar tumors. Utilizing advanced neuroimaging and navigation, he employs keyhole neurosurgery to minimize disruption to surrounding structures, reducing post-operative pain and complications while promoting faster recovery. His expertise also extends to a range of minimally invasive spine procedures, including anterior cervical discectomy and fusion, artificial cervical disc arthroplasty, and posterior cervical fusion with instrumentation. Dedicated to innovation, he continuously integrates the latest advancements in neurosurgical techniques to improve patient outcomes. </span></p> <p dir="ltr"><span>Beyond his clinical practice, Dr. Louis is deeply involved in research, with a particular interest in microsurgical neuroanatomy and the development of novel neurosurgical procedures. He has authored over 60 peer-reviewed scientific publications and contributed to numerous book chapters, furthering the field’s understanding of neuroanatomy and surgical advancements. His commitment to both patient care and research ensures that he remains at the forefront of neurosurgery, offering cutting-edge treatments that enhance both safety and efficacy. </span></p> </div>

Dr. Ezequiel Goldschmidt is a fellowship-trained neurosurgeon who specializes in the care of patients with skull base and brain tumors. Originally from Argentina, Dr. Goldschmidt earned both his MD and PhD from the prestigious Buenos Aires University Medical School. He completed his neurosurgery residency and cranial base surgery fellowship at the University of Pittsburgh, one of the leading centers in this field and the birthplace of modern endonasal surgery. He was then awarded the prestigious Van Wagenen Fellowship—a rare honor given biennially—where he advanced his research at the Karolinska Institute in Sweden, a world-renowned hub for neuroscience and home of the Nobel Prize in Physiology or Medicine. There, Dr. Goldschmidt developed a novel experimental brain bypass surgery, which he currently studies at the Weill Institute in Berkeley. A committed physician-scientist, Dr. Goldschmidt has led impactful research efforts at the intersection of neurosurgery and technology. He has received multiple prestigious awards including the joint UCSF and UC Berkeley Bakar fellowship where he leads a multidisciplinary team to design soft robots, able to enhance and advance minimally invasive brain surgery. With over 700 skull base surgeries since 2021, his clinical acumen is matched by an impressive research portfolio that is set to produce over 90 publications, numerous grants as well as national and international presentations. Dr. Goldschmidt is a fellow of the Congress of Neurological Surgery and the American Association of Neurological Surgeons, where he is a member of the tumor committee; he also sits on the board of directors of the California Association of Neurological Surgeons and is an active member and lecturer at the North American Skull Base Society. He is an active scientist and holds appointments both at UCSF and UC Berkeley. Beyond his surgical precision and academic career, Dr. Goldschmidt is driven by a personal mission to reduce the impact of brain surgery in patients’ lives. From a young age, he discovered his passion for medicine through a high school that valued scientific curiosity and critical thinking.. Known for his warm, communicative approach, Dr. Goldschmidt ensures patients and families can always reach him directly at all times—because healing extends beyond the operating room. Outside the hospital, he enjoys time with his family and pets (that are like family), swimming, mentoring future neurosurgeons, and constantly exploring opportunities to better the brain health of our community. A full list of Dr. Goldschmidt's publications can be found here: https://pubmed.ncbi.nlm.nih.gov/?term=ezequiel+goldschmidt&sort=date"

Dr. Christopher Duma is one of the most experienced neurosurgeon specialists in the field of Gamma Knife radiosurgery and brain tumor surgery. Dr. Duma has been performing Gamma Knife radiosurgery since 1990, and brings to Hoag patients an incredible level of physician expertise. Dr. Duma treats nearly 200 patients per year and because he also performs open, general cranial neurosurgery, he is uniquely equipped to offer an unbiased opinion about the management of any particular problem. In addition to his work with the Gamma Knife, Dr. Duma is involved with research in gene therapy, genetically engineered cells and vaccines to fight malignant brain tumors. He has also been at the forefront of research in immunotherapy for primary brain tumors and the treatment of Parkinson’s disease. Dr. Duma has authored numerous articles, studies and book chapters, and continues to investigate new clinical applications for stereotactic radiosurgery.

Mehta is Neurosurgeon with particular expertise in complex and minimally invasive brain and spine surgery. He is a member of the Hoag Epilepsy Surgery Program at the Pickup Family Neurosciences Institute.  He was raised in Orange County and completed medical school with Alpha Omega Alpha Honors at The Johns Hopkins University School of Medicine. In college, he was named to the USA Today All-Academic First Team as one of the top 20 colleges students in the United States.  After completing medical school, Dr. Mehta completed advanced training in neurosurgery at the University of Southern California under Drs. Michael Apuzzo, Martin Weiss, Gordon McComb and Steven Giannotta and in Epilepsy and Stereotactic Neurosurgery with Dr. Charles Liu.  Prior to joining Hoag, he was on staff at the University of Southern California as an attending neurosurgery at Los Angeles County + USC Medical Center, the nations busiest Level 1 neurosurgery trauma center.  He is an Adjunct Assistant Professor of Clinical Neurosurgery at the USC Keck School of Medicine.

<div> <p dir="ltr"><span>Simon Khagi, MD, is Medical Director of Neuro-Oncology at Hoag Family Cancer Institute and a board certified medical and neurological oncologist. Dr. Khagi’s areas of expertise include treating primary brain and spine cancers, as well as lung cancers and advanced skincancers. His areas of expertise include: immunotherapy, genomically-guided therapy, oncolytic virotherapy, adoptive cell therapy (i.e. NK and chimeric antigen receptor T cells), and alternating tumor treating fields. He has significant experience with glioblastoma, astrocytoma, oligodendroglioma, meningioma, ependymoma, medulloblastoma, germ cell tumors, brain metastases, rare brain tumors, lung cancers, melanoma, and other advanced skin cancers.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi has always felt a strong connection with patients and families battling cancer. His desire to help them motivated him to become an oncologist. According to Dr. Khagi, he considers quality and quantity of life as two sides of the same coin when supporting his patients. Valuing both is a cornerstone of the care he provides.</span></p> <p><span> </span></p> <p dir="ltr"><span>Previously, Dr. Khagi was an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. He also served as an Associate Oncology Service Line Director and Regional Medical Director at Dartmouth Cancer Center. Prior to joining Dartmouth, Dr. Khagi served as the Director of the Neuro-Oncology and Brain Metastases Program at the University of North Carolina at Chapel Hill UNC.</span></p> <p><span> </span></p> <p dir="ltr"><span>Dr. Khagi is active in clinical research, having conducted numerous clinical trials focusing on glioblastoma, meningioma, advanced glioma, and brain metastases, among others. While at UNC, he led many novel research protocols, including the first institutional use of a live virus delivered directly into the brain against brain tumors, in addition to contributing to the development of a novel CAR T cell technology for glioblastoma. To date, Dr. Khagi has authored or co-authored over fifty book chapters, peer-reviewed manuscripts and abstracts. Selected list of publications.</span></p> <p><span> </span></p> <p dir="ltr"><span>Having received multiple honors throughout his career and being inducted as a fellow of the American College of Physicians, Dr. Khagi has also received the “Healthcare Hero Award” from the Head for the Cure Foundation and the “Exemplary Service Award” from the UNC Division of Medical Oncology along with multiple research grants.</span></p> <p><span> </span></p> <p dir="ltr"><span>Dr. Khagi feels strongly about raising awareness of the societal burden of cancer and speaks regularly at community outreach events, in addition to sitting on multiple advisory boards focused on improving cancer care.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi has always felt a strong connection with patients and families battling cancer. The desire to help them motivated him to become an oncologist. According to Dr. Khagi, he considers quality and quantity of life as two sides of the same coin when supporting his patients. Valuing both is a cornerstone of the care he provides. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Previously, Dr. Khagi was an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. He also served as an Associate Oncology Service Line Director and Regional Medical Director at Dartmouth Cancer Center. Prior to joining Dartmouth, Dr. Khagi served as the Director of the Neuro-Oncology and Brain Metastases Program at the University of North Carolina at Chapel Hill UNC. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi is active in clinical research, having conducted numerous clinical trials focusing on glioblastoma, meningioma, advanced glioma, and brain metastases, among others. While at UNC, he led many novel research protocols, including the first institutional use of a live virus delivered directly into the brain against brain tumors, in addition to contributing to the development of a novel CAR T cell technology for glioblastoma. To date, Dr. Khagi has authored or co-authored over fifty book chapters, peer-reviewed manuscripts and abstracts. Selected list of publications.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Having received multiple honors throughout his career and being inducted as a fellow of the American College of Physicians, Dr. Khagi has also received the “Healthcare Hero Award” from the Head for the Cure Foundation and the “Exemplary Service Award” from the UNC Division of Medical Oncology along with multiple research grants. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi feels strongly about raising awareness of the societal burden of cancer and speaks regularly at community outreach events, in addition to sitting on multiple organizational boards focused on improving cancer care.</span></p> </div>
Hoag’s Precision Medicine Program combines genomics and genetics to diagnose, treat, and prevent diseases. Using the latest advances in genomic technologies, targeted therapies and research, our precision medicine program brings together a multidisciplinary team, including a robust genetic counseling group of experts, to provide patients with the latest in innovation and technology.
Being diagnosed with cancer can feel overwhelming at times. Many patients and their families need help with coping and can benefit from supportive counseling. Oncology Clinical Social Workers are available to provide emotional and practical support during all stages of cancer including diagnosis, treatment and post-treatment survivorship.
Hoag Family Cancer Institute dietitians work closely with patients’ physicians, nurses, therapists, and social workers to ensure complete care.
First, at Hoag you are not alone. A cancer diagnosis is the start of a significant journey for you, your family and caregivers and we are with you every step of the way. Hoag’s world-class expertise, leading-edge technology and the latest in diagnostic and treatment options for cancer are enhanced by our rich array of empowering resources and services to prepare, assist and comfort you before, during and after cancer treatment.
We encourage you and your family to join our virtual patient and family orientation class to learn more about Hoag Family Cancer Institute. The class provides information, support and will address questions to help you better prepare for your cancer journey.
Orientations are held the 4th Tuesday of each month from 1:00 – 2:00 p.m. via ZOOM meeting.
Registration is easy, simply go to our orientation registration page and explore available dates. Once you find a date that works for you, select ‘register’ and fill out the information form. We encourage you to contact us along the way with any questions at 949-722-6237.
Classes can be found at https://www.hoag.org/community-education-classes/
The supportive care and survivorship program at Hoag Family Cancer Institute provides care to enhance your quality of life throughout all stages of treatment and recovery. Our supportive care team provides a dedicated nurse navigator, expert pain and symptom management, tools for your mental and physical wellbeing, and so much more. Our goal is to address your changing needs and support you through your cancer treatment and beyond. Below is a full list of our services:
Navigating Life After Diagnosis
Classes & Support Services
Hoag is the top choice for cancer care in Orange County, with cancer survival rates that continually exceed national averages. Our dedicated, world-class teams are wholly focused on helping you survive cancer, heal and move forward with your life.
Brain tumors are abnormal masses of cells that can occur within the brain. These tumors can be either malignant (cancerous) or benign (non-cancerous). However, because brain tumors occur in the complex, delicate organ that controls most of our bodily functions — including thinking, memory, breathing, speech, vision, hearing and dozens of other important processes — all brain tumors are considered dangerous to a person’s health.
While malignant brain tumors don’t often spread (or “metastasize”) to other parts of the body, malignant brain tumors often spread to other parts of the brain. While benign brain tumors are not likely to spread, they can intrude on and press against healthy brain tissue as they grow, causing damage to the brain and life-threatening effects.
Tumors that begin in the brain are called “primary brain tumors.” However, other types of cancer that start in the body can spread to the brain. This results in what are called “secondary brain tumors” or “metastatic brain cancer.”
According to the American Cancer Society, brain tumors are classified based on several different factors. These factors often guide both the treatment path and prognosis.
Brain tumors are usually assigned what’s called a “grade.”
There are many different types of brain tumors, each usually classified by where they start in the brain or the type of cells they started from. Types of brain tumors include:
Both cancerous and non-cancerous brain tumors cause symptoms that can severely impact a person’s health. These symptoms can be caused by malignant tumors spreading to other parts of the brain, or non-cancerous tumors pressing on nerves, the pituitary gland, spinal cord or brain tissue. Brain tumors can also increase what’s called intracranial pressure inside the skull, either through the growth of the tumor, causing the brain to swell, or blocking the movement of cerebrospinal fluid that the brain needs to function.
According to the American Cancer Society, symptoms caused by increased intracranial pressure due to a brain tumor can include:
Issues with balance or walking
Other symptoms related to brain tumors can vary, depending on the part of the brain in which the tumor occurs. According to the American Cancer Society, these symptoms can include:

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